Management of type 2 diabetes mellitus, especially in overweight patients, when diet and exercise alone do not provide adequate glycemic control.
Metformin works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake.
Initial dose: 500 mg once daily with evening meal. Dosage can be adjusted based on patient response, up to a maximum of 2000 mg/day.
Should be taken with food to reduce gastrointestinal side effects. Swallow whole, do not crush or chew.
May interact with alcohol, diuretics, corticosteroids, and other antidiabetic agents. Co-administration with iodine contrast agents may increase risk of lactic acidosis.
Renal dysfunction, metabolic acidosis (including diabetic ketoacidosis), severe hepatic impairment, and hypersensitivity to Metformin.
Nausea, vomiting, diarrhea, abdominal pain, metallic taste. Rarely, lactic acidosis may occur.
Should be used during pregnancy only if clearly needed and prescribed by a physician. Use with caution during lactation.
Monitor renal function regularly. Avoid alcohol. Stop treatment temporarily before surgery or use of contrast agents.
Biguanides (Oral hypoglycemics)
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.