Nebita Plus 5/12.5 mg Tablet is a combination antihypertensive medication that contains Nebivolol (5 mg), a cardioselective beta-1 blocker, and Hydrochlorothiazide (12.5 mg), a thiazide diuretic. This formulation is designed for patients who require more than one drug to achieve optimal blood pressure control. Nebivolol works by slowing the heart rate and relaxing blood vessels, which helps lower blood pressure and improve blood flow. Hydrochlorothiazide complements this action by reducing excess fluid in the body through urination, further decreasing blood pressure. Together, these agents offer a synergistic effect, making Nebita Plus especially effective in treating mild to moderate essential hypertension. It is typically taken once daily and should be used under medical supervision, especially in patients with kidney, liver, or heart conditions.